Open Evidence
Last Updated on: Sep 12, 2025
Open Evidence
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What is Open Evidence?
OpenEvidence is a cutting-edge, AI-powered clinical decision support platform tailored for healthcare professionals. Developed through the Mayo Clinic Platform Accelerate program, it offers instant, evidence-based answers to medical queries—citing sources from leading journals such as NEJM and JAMA. Trusted in 10,000+ U.S. care centers and free to verified clinicians, the app delivers peer-reviewed, multimedia-backed insights at the point of care.
Who can use Open Evidence & how?
  • Physicians & Clinicians: Get rapid, evidence-based responses to clinical questions during patient care.
  • Medical Trainees & Students: Triage symptoms, build differential diagnoses, and study with confidence.
  • Medical Educators: Use the tool for teaching, curriculum development, and case-based learning.
  • Healthcare Researchers: Aggregate, synthesize, and visualize peer-reviewed evidence for studies and protocols.
  • Hospital Administrators: Leverage for protocol standardization and point-of-care knowledge dissemination.

🛠️ How to Use OpenEvidence?
  • Verify Your HCP Status: Sign up with an approved NPI to unlock access.
  • Download the App: Available on iOS, Android, and web.
  • Search or Chat: Enter clinical questions, upload images, or input case notes.
  • Review the Answer: View clear summaries with inline citations, images, tables, and direct links to references.
  • Explore Further: Dive deeper with suggested follow-up questions or literature links.
What's so unique or special about Open Evidence?
  • Peer-Reviewed Sources: Utilizes NEJM, JAMA, PubMed abstracts—ensuring high-quality, evidence-based output.
  • Multimedia Integration: Includes journal images, figures, and tables for richer comprehension.
  • Fully Cited Answers: Inline references with PubMed links let you verify sources instantly.
  • Clinician Testing: Rated 4.9★ by over 3,000 HCPs in app stores.
  • Free for Clinicians: No cost to verified U.S. providers—trusted by tens of thousands of medical institutions.
Things We Like
  • Medical Grade Expertise: Provides fast, reliable answers that's like having expert journals in your pocket.
  • Speedy Responses: Access evidence-based summaries more quickly than traditional searches.
  • Trusted Credibility: Feedback from institutions like Mayo Clinic, Cedars-Sinai, and Harvard validates its value.
  • Cross-Platform Access: iOS, Android, and web interfaces are seamless and responsive.
  • Clinical Integration Ready: Ideal for rounds, consults, research, and continuous learning.
Things We Don't Like
  • Not a Diagnostic Tool: Offers guidance not replacements—clinical judgment remains essential.
  • HCP Required: You must be a verified healthcare professional—no patient access allowed.
  • Focus on Summaries: Not ideal for deep reviews or research—best for quick-reference queries.
  • US-Centric Data: Primary source materials come from U.S. journals—non-U.S. users should verify applicability.
  • Occasional Slowness: Some pubmed-intensive queries might take longer to return results.
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FAQs

Verified U.S. health care professionals (NPI required) only.
Yes—completely free for verified clinicians with no usage limits.
Over 1M topics, 160+ specialties, and 1,000+ disease areas—from acute care to chronic diseases.
Yes—all responses are fully cited with links to peer-reviewed journals and PubMed.
It includes NEJM, JAMA Network, and other top-tier medical sources.

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